Liver Failure Protein Identified

© MAS1988
There is good news for all those concerned about proteins linked to liver damage. A recent discovery has come up with the protein Sab, or SH3-domain binding protein 5, as an important precursor to liver damage prevention. The damage is mostly due to medications like acetaminophen, or the everyday Tylenol. Acetaminophen is the most common reason of a liver disease and/or liver failure ushered in by drug use in the States and U.K.
The research work comes from the Keck School of Medicine of the University of Southern California (USC), who discovered that inhibition of the protein saves the liver from acetaminophen toxicity.
The research revealed that the protein on the mitochondria of liver cells in mice, when silenced, protects against liver toxicity by inhibiting a protein enzyme (JNK) which is activated by the drug and te over-expressiion of which leads to cell death.
